|First appearance:||The Wedding Frame|
|Voiced by:||Grey DeLisle|
Diane Francis is Dr. Dave's old girlfriend. She only appeared in The Wedding Frame. At Dave and Lois' wedding, Dave's mother hired Nikki LaPorte (actually Nicholas LaPorte) to play the role of Diane to ruin the wedding. But Noelle sabotaged Mrs. Dave's plan and exposed her treachery by bringing in the real Diane. She is voiced by Grey DeLisle.
At some point before the series Diane Francis and Dr. David Dave used to date, however they broke up and moved on. They meet again during The Wedding Frame when Noelle exposes Mrs. Dave's plot to break Dave and Lois apart.
- She only appears in the final episode of the series.