Of Lice and Friends is the fifth episode of the first season which was broadcast on November 22, 2000.
There is a lice-outbreak at Lucky Jr. High as Dodie becomes the new school announcer. Ginger feels that Dodie goes overboard with her job when Dodie turns it into a gossip column. Dodie finds the list of kids who were found to have lice during the inspection and feels that the other students have the right to know so they can avoid getting lice, one of which is Courtney. Ginger is able to stop her from reading most of the list over the announcements. Meanwhile, Carl and Hoodsey sabotage Blake's experiment to give flies multi-colored wings.
- Ginger Foutley
- Carl Foutley
- Courtney Gripling
- Macie Lightfoot
- Hoodsey Bishop
- Dodie Bishop
- Miranda Killgallen
- Darren Patterson
- Lois Foutley
- Blake Gripling
- Mipsy Mipson
- Ms. Zorski
- Principal Milty
- Chet Zipper
- Hall Monitor
- Mr. Pringle
- Mrs. Fleming
- Stuart Higsby (cameo)
- Hope Rogers (cameo)
- Vince (cameo)
Courtney: Well, we are in the middle of an epidemic, and La Courtney isn't taking any chances, Dodie.
Courtney: From now on, I wash my hair four times a day instead of the usual two.
Courtney: Perhaps you're just not clear on the fact that I'm famous for being pretty, popular, and spotlessly clean.
Ginger: Archery? When will that ever come up in real life?
Carl: You can watch flies for free at the city dump. Hoodsey: And we've done it, too.
Courtney: Let me see if I understand you. The fact that I've been showering obsessively to keep the lice at bay has actually led me down the cootie path of no return?
- The title of the episode is a reference to the novel (and film adaptations) Of Mice and Men by author John Steinbeck.
- Courtney and Miranda's outfits at the beginning of the episode is similar to the same clothing style from the 1995 film Clueless.
- Darren appears in this episode, but he does not speak.
- The sentence that Ms. Zorski writes on the chalkboard reads "Homeroom is a room you should treat like home".